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Are sufficient details of the methods and analysis provided to allow replication by others?

Partly

Is the statistical analysis and its interpretation appropriate?

Not applicable

Are the conclusions drawn adequately supported by the results presented in the review?

I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.
CITE
Perret C. Referee Report For: Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review [version 2; referees: 2 approved, 1 approved with reservations] . 2017, :390 (doi: 10.5256/f1000research.11949.r21386 )
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Author Response 02 五月 2017
Alfonso Rodriguez-Morales , Universidad Tecnológica de Pereira, Colombia
02 五月 2017
Author Response
Dear Dr. Perret Thanks for your valuable comments. Certainly the topic of this systematic review (without meta-analysis), is on ongoing findings that in the near future will be better defined. Regard your assessment, unfortunately this arrived when two others reviews ago had been submitted; based on them, we have recently proceeded to develop the new revised version. Your comments are consistent with those from Dr. Vilcarromero in a significant magnitude. Then, most of your comments are addressed in the revised version of the paper, including clarification on the objectives as well on the Methodology (explaining more the search criteria as well the clarification regard the use of PRISMA checklist and flow diagram). Regard the language of articles included, we agree that this would be a limitation. Limitations are now better described in the new version of the article. As we explained, dengue cardiovascular compromise and manifestations was a necessary comparison for understanding of readers. In the new version, Discussion and Conclusions were improved.
Competing Interests:
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COMMENTS ON THIS REPORT
Author Response 02 五月 2017
Alfonso Rodriguez-Morales , Universidad Tecnológica de Pereira, Colombia
02 五月 2017
Author Response
Dear Dr. Perret Thanks for your valuable comments. Certainly the topic of this systematic review (without meta-analysis), is on ongoing findings that in the near future will be better defined. Regard your assessment, unfortunately this arrived when two others reviews ago had been submitted; based on them, we have recently proceeded to develop the new revised version. Your comments are consistent with those from Dr. Vilcarromero in a significant magnitude. Then, most of your comments are addressed in the revised version of the paper, including clarification on the objectives as well on the Methodology (explaining more the search criteria as well the clarification regard the use of PRISMA checklist and flow diagram). Regard the language of articles included, we agree that this would be a limitation. Limitations are now better described in the new version of the article. As we explained, dengue cardiovascular compromise and manifestations was a necessary comparison for understanding of readers. In the new version, Discussion and Conclusions were improved.
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How to cite this report:
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Referee Report 18 四月 2017
Stalin Vilcarromero , Sociedad Científica de Estudiantes de Medicina de la Amazonía Peruana (SOCIEMAP), Facultad de Medicina, Universidad Nacional de la Amazonía Peruana, Iquitos, Peru; Naval Medical Research Unit № 6, Lima Iquitos, Peru
Approved with Reservations
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DOI: 10.5256/f1000research.11949.r21382
In the manuscript entitled “Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review” authors have made a hard and interesting description of the cardiovascular effect by chikungunya virus infection. This analysis would be important to share with the scientific community; however it is necessary major changes in order to be ready for publication. Mainly, focus in the specific topic and put in order and properly the information in the paper. It s not clear, author start assessing that the objective focus among cardiovascular involvement and manifestation, however, other systemic manifestation or atypical manifestation also become relevant in the results section. Authors say, “The key for a successful outcome of CHIKV-induced cardiomyopathy is recognizing signs and symptoms”. Here I recommend repeating the most important ones. This section would consider some of the bias common to this kind of study where there is no clinical trials included and where “case reports” were including. Bias such as “selection” or “publication” bias, etc.

Referee Expertise: epidemiology and clinic of Arbovirus infection

Likewise, a finite family of σ-algebras ( τ i ) i I {\displaystyle (\tau _{i})_{i\in I}} , where I {\displaystyle I} is an from china free shipping Nicholas Kirkwood Lola pearl sock pumps clearance supply buy online outlet nwbOdC1
, is said to be independent if and only if

and an infinite family of σ-algebras is said to be independent if all its finite subfamilies are independent.

The new definition relates to the previous ones very directly:

Using this definition, it is easy to show that if X and Y are random variables and Y is constant, then X and Y are independent, since the σ-algebra generated by a constant random variable is the trivial σ-algebra {∅,Ω}. Probability zero events cannot affect independence so independence also holds if Y is only Pr- almost surely constant.

Note that an event is independent of itself if and only if

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If X and Y are independent, then the expectation operator E has the property

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(The converse of these, i.e. the proposition that if two random variables have a covariance of 0 they must be independent, is not true. See uncorrelated .)

Two random variables X and Y are independent if and only if the characteristic function of the random vector ( X , Y ) satisfies

In particular the characteristic function of their sum is the product of their marginal characteristic functions:

though the reverse implication is not true. Random variables that satisfy the latter condition are called subindependent .

The event of getting a 6 the first time a dice is rolled and the event of getting a 6 the second time are independent . By contrast, the event of getting a 6 the first time a dice is rolled and the event that the sum of the numbers seen on the first and second trial is 8 are not independent.

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